Cancer BiologybioRxiv
Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib
Ying Pang, Qi Li, Zach Sergi…·Jing Wu
This paper identifies zotiraciclib as a therapeutic agent targeting IDH-mutant gliomas by disrupting mitochondrial function and inducing oxidative stress, leading to a clinical trial.
DOI 10.1016/j.isci.2025.112283