ImmunologyhLifePeer-reviewed
Targeted protein degradation via CAR endocytosis of antigen in T cells
Youguang Wang, Zihao He, Na Yin, Min Peng
This paper develops a TPD platform using CAR T cells to degrade extracellular TNF, achieving disease remission in a rheumatoid arthritis model.
DOI 10.1016/j.hlife.2026.05.003