Author

Marcus Saarinen

Karolinska InstitutetORCID 0000-0001-9019-8396Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

Per SvenningssoniD· 3 shared Jens CarlssoniD· 2 shared Lucie DelemotteiD· 2 shared Yue Chen· 2 shared Akshay S. NaraineiD· 1 shared Annika BendesiD· 1 shared Emilie CeraudoiD· 1 shared Ilana B. KotliariD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersBiophysics

Per SvenningssonORCID

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3 papers

Recent·Most cited

BiophysicsBMC BiologyPeer-reviewedFeb 5, 2026

Computational design of constitutively active mutants of Dopamine D2 receptor inspired by ligand-independent activation mechanisms

Yue Chen, Marcus Saarinen, Akshay S. Naraine…·Lucie Delemotte

The paper identifies a constitutively active mutant of the dopamine D2 receptor using computational methods and experimental validation.

1 citation

humandeep learning

𝕏 PostBluesky

BiophysicsbioRxivPreprintMar 30, 2025

Revealing molecular determinants of ligand efficacy and affinity at the D2 dopamine receptor through molecular dynamics simulations

Yue Chen, Nour Aldin Kahlous, Marcus Saarinen…·Jens Carlsson

This study uses molecular dynamics simulations to uncover the molecular mechanisms of ligand activation in the D2 dopamine receptor and identifies differences in activation mechanisms between dopamine and adrenergic receptors.

1 citation

mechanistic / dynamical modeldrug response / drug discovery

𝕏 PostBluesky

BiochemistryScience AdvancesPeer-reviewedJul 31, 2024

Expanding the GPCR-RAMP interactome

Ilana B. Kotliar, Annika Bendes, Leo Dahl…·Thomas P. Sakmar

The paper identifies 122 GPCRs interacting with RAMPs using a DuET library and SBA assay, expanding the GPCR-RAMP interactome to inform therapeutic design.

10 citations

experimental assaycell type annotation

𝕏 PostBluesky