Craniofacial dysmorphology in Down Syndrome is caused by increased dosage of Dyrk1a and at least three other genes
Yushi T. Redhead, Dorota Gibbins, Eva Lana‐Elola…·Victor L. J. Tybulewicz
The paper identifies four Hsa21-orthologous genes, including Dyrk1a, that cause craniofacial dysmorphology in Down syndrome mouse models by reducing neural crest cell proliferation.