An Alternatively Spliced Gain-of-Function NT5C2 Isoform Contributes to Chemoresistance in Acute Lymphoblastic Leukemia
M. T. Diz, C. Reglero, C. D. Falkenstein, A. Castro, K. E. Hayer, C. Radens, M. Quesnel-Vallieres, Z. Ang, P. Sehgal, M. M. Li, Y. Barash, S. K. Tasian, A. Ferrando, A. Thomas-Tikhonenko
The paper identifies an alternatively spliced NT5C2 isoform contributing to chemoresistance in B-ALL by enhancing nucleosidase activity and 6-MP resistance.
bioRxiv · Sep 14, 2023Cancer Biology