C. Schmidt

SiRCle (Signature Regulatory Clustering) model integration reveals mechanisms of phenotype regulation in renal cancer

SiRCle integrates multi-omics data to identify regulatory mechanisms and survival-associated markers in clear cell renal cell carcinoma.

Minimized Sample Consumption for Time-Resolved Serial Crystallography Applied to the Redox Cycle of Human NQO1

This paper demonstrates a method to reduce sample consumption in time-resolved serial crystallography by using segmented droplet generation and mix-and-inject approaches for studying NQO1's redox cycle.

Variations of autonomic arousal mediate the reportability of mind-blanking occurrences

The paper shows that variations in autonomic arousal influence the likelihood of reporting mind-blanking events, with both low and high arousal conditions associated with increased reports.

A perfusion-independent high-throughput method to isolate liver sinusoidal endothelial cells

This paper introduces a perfusion-independent method to isolate liver sinusoidal endothelial cells with high purity and throughput, comparable to perfusion-dependent methods.

Urbanization is associated with reduced genetic diversity in marine fish populations

The paper assesses the impact of urbanization on marine fish genetic diversity using population genetic datasets, finding reduced diversity in areas with higher human population density.

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma

This paper develops a mouse model for high-risk sarcoma by delivering genetic lesions via electroporation, generating multiple sarcoma types and validating their molecular and therapeutic relevance.

Climate change, age acceleration, and the erosion of fitness in polar bears

This study links climate change to accelerated epigenetic aging in polar bears, reduced fitness, and near-zero adaptive potential.

ATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

This study shows ATF6 activation in colonic epithelial cells alters lipid metabolism, promoting tumor-associated microbial adaptation in mice and human colorectal cancer patients.

Migration distance and mating system are not associated with genetic diversity and differentiation among bats (Chiroptera)

The paper examines the relationship between migration and mating strategies and genetic diversity in bats, finding no significant correlations.

Light-induced Trpin/Metout switching during BLUF domain activation in ATP-bound photoactivatable adenylate cyclase OaPAC

This study investigates the light-induced structural changes in OaPAC's BLUF domain, revealing a Trpin/Metout transition and conformational shifts during ATP activation.

PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression

This study shows PRDM6 represses chromatin accessibility and alters gene expression in neuroepithelial stem cells, promoting medulloblastoma but not sufficient to drive Group 4 medulloblastoma alone.

Uncovering the Environmental Conditions Required for Phyllachora maydis Infection and Tar Spot Development on Corn in the United States for Use as Predictive Models for Future Epidemics

Alternative splicing of its 5'-UTR limits CD20 mRNA translation and enables resistance to CD20-directed immunotherapies

This study identifies alternative splicing of CD20 mRNA that generates translation-deficient isoforms, contributing to resistance to CD20-directed immunotherapies.

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography

This paper introduces a mix-and-extrude method for time-resolved protein crystallography using 3D printed microchannels to study ligand-induced reactions in viscous media.

Nucleotide-free structures of Kif20A illuminate the atypical allostery in this mitotic kinesin-6

This paper presents the first high-resolution structure of Kif20A's motor domain, revealing structural features and allostery mechanisms that explain its atypical motility and ATPase activity.

Gene regulatory network inference in soybean upon infection by Phytophthora sojae

This study uses transcriptome and deep learning to infer gene regulatory networks in soybean responding to Phytophthora sojae infection, identifying key transcription factors involved in defense.

Evolutionary history of Euteliidae (Lepidoptera, Noctuoidea)

This study reconstructs the evolutionary history of Euteliidae moths, revealing their adaptation to resinous and latex-producing plants and identifying taxonomic revisions and divergence times.

SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design

This study identifies three natural compounds that inhibit SARS-CoV-2 PLpro by binding to the ISG15/Ub-S2 allosteric site, showing antiviral activity and potential for drug design.

FOXA2 controls the anti-oxidant response in FH-deficient cells

This study identifies FOXA2 as a key transcription factor regulating the anti-oxidant response in FH-deficient cells, independent of NRF2, and highlights its role in metabolic rewiring.

HIRA loss transforms FH-deficient cells

This study identifies HIRA depletion as a factor that enhances proliferation and invasion of Fh1-deficient cells, revealing a mechanism involving MYC activation and nucleotide metabolism.

Biogeography and taxonomy of the Hemileuca maia-nevadensis Stretch species complex (Lepidoptera: Saturniidae): insights to the midcontinental populations

The paper assesses the geographic distribution, genetic variation, and reproductive barriers of Hemileuca maia-nevadensis populations, identifying distinct species within the complex.

Neuronal glucose metabolism sets cholinergic tone and controls thermo-regulated signaling at the neuromuscular junction

This study shows that increasing glycolysis in cholinergic neurons boosts acetylcholine levels, reduces blood pressure and heart rate, and improves cold resistance.

Population demography maintains biogeographic boundaries

The paper shows that populations near biogeographic transition zones have lower genetic diversity and effective population sizes, suggesting reduced adaptive capacity and maintaining biogeographic boundaries.

Fbxo7 promotes Cdk6 activity to inhibit PFKP and glycolysis in T cells.

This study identifies Fbxo7's role in promoting Cdk6 activity to inhibit PFKP and glycolysis in T cells, revealing its impact on metabolism and viability.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

This study identifies TRIM67 as an oncogene in oligodendrogliomas that promotes cell motility, tumor growth, and membrane blebbing through Rho GTPase/ROCK signaling.

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

MEOX2 homeobox gene promotes growth of malignant gliomas

This study identifies MEOX2 as an oncogenic transcription factor in glioblastoma, showing it promotes tumor growth through ERK signaling and cooperates with p53 and PTEN loss.

A chemotactic sensor controls Salmonella-host cell interaction

The paper shows that the chemotactic sensor CheM controls Salmonella's ability to invade host cells by regulating the surface retention of the adhesin SiiE.

A multiplex microchamber diffusion assay for the antibody-based detection of microRNAs on randomly ordered microbeads

This paper introduces a multiplex microchamber diffusion assay for antibody-based miRNA detection, showing real-time, simultaneous detection without amplification steps.