LGR4 is essential for maintaining beta-cell homeostasis through suppression of RANK
J. Filipowska, Z. Cisneros, N. Leon-Rivera, P. Wang, R. Kang, G. Lu, Y.-C. Yuan, S. Bhattacharya, S. Dhawan, A. Garcia-Ocana, N. G. Kondegowda, R. C. Vasavada
This study shows LGR4 maintains beta-cell health by suppressing RANK, with effects observed in both in vitro and mouse models under stress and aging.
bioRxiv · May 10, 2024Physiology