Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
A. Kroupova, V. A. Spiteri, H. Furihata, D. Darren, S. Ramachandran, Z. Rutter, S. Chakraborti, K. Haubrich, J. Pethe, D. Gonzales, A. Wijaya, M. Rodriguez-Rios, D. M. Lynch, W. Farnaby, M. Nakasone, , A. Ciulli
The paper introduces CRBNmidi, a Cereblon construct that enables high-resolution structural and biophysical studies of degraders without requiring DDB1 co-expression.
Nature Communications · Oct 15, 2024Peer-reviewedBiochemistry