M. Winkler

Tyrosine halogenation converts α-defensins into potent immunomodulators

The paper identifies that tyrosine halogenation of α-defensins by hypohalous acids converts them into immunomodulatory mediators, revealing a novel oxidative mechanism in neutrophil function.

Differential substrate affinity and catabolite repression enable preferential use of urea by ammonia-oxidizing bacteria

The paper shows that ammonia-oxidizing microorganisms use different regulatory strategies for ammonia and urea, enabling coexistence by minimizing competition.

The hGID GID4 E3 ubiquitin ligase complex targets ARHGAP11A to regulate cell migration

This study identifies GID4 as a substrate receptor of the hGID E3 ligase complex that targets ARHGAP11A for degradation, thereby regulating cell migration.

Development of immortalized rhesus macaque kidney cells supporting infection with a panel of viruses

The paper reports the generation of TERT-immortalized rhesus macaque kidney cell lines susceptible to infection by multiple viruses including Zika and primate herpesviruses.

Primate simplexviruses differ in tropism for macaque cells

This study compares the tropism of primate simplexviruses in macaque and human cells, finding that McHV1 and PaHV2 replicate efficiently in rhesus macaque cells while HSV1, HSV2, and CeHV2 do not.

Apremilast prevents blistering in human epidermis by stabilization of keratinocyte adhesion in pemphigus.

This study shows apremilast stabilizes keratinocyte adhesion in pemphigus by phosphorylating plakoglobin at serine 665, preventing blistering without affecting desmoglein depletion or binding.

Repurposing screen highlights broad-spectrum coronavirus antivirals and their host targets

The paper screens a drug library to identify broad-spectrum coronavirus antivirals and their host targets, finding compounds that inhibit both alpha- and beta-coronaviruses.

Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system

This study shows that neuropilin-1 enhances SARS-CoV-2 infectivity and facilitates viral entry into the central nervous system via the olfactory pathway.

Sustained nitrogen loss in a symbiotic association of Comammox Nitrospira and Anammox bacteria

The paper examines the ecological relevance of Comammox Nitrospira and Anammox bacteria coexistence by establishing synthetic communities that enable sustained nitrogen loss through dinitrogen gas production.

Resource limitation modulates the fate of dissimilated nitrogen in a dual-pathway Actinobacterium

The paper shows that resource limitation in Intrasporangium calvum C5 favors ammonification over denitrification, driven by redox poise rather than C:NO3- ratio.

The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes

This study identifies GpsB as a cytosolic adaptor that coordinates cell wall synthesis with the bacterial cell cycle by interacting with multiple enzymes and proteins.