H.-C. T. Tsui

This study identifies three types of single-molecule motions of PG synthesis proteins in Streptococcus pneumoniae, revealing zonal, circumferential movement of core elongasome proteins and distinct behaviors of aPBP1a and MpgA.

This paper identifies a novel pathway for mnm5s2U synthesis in Gram-positive bacteria, revealing alternative biosynthetic mechanisms involving the MnmL enzyme.

The paper identifies genetic modifications in Streptococcus pneumoniae that bypass the need for protein phosphorylation by altering MurZ and MurA activity.

This study investigates the role of RodZ and PBP1b in the PG elongasome of ovoid-shaped Streptococcus pneumoniae, showing RodZ as a scaffolding protein and PBP1b's involvement in elongasome regulation.

This paper investigates the spatial organization of peptidoglycan synthesis in Streptococcus pneumoniae during cell division, revealing distinct rings and nodes of transpeptidase activity and PBP localization.

This paper identifies CvfD, an S1-domain RNA-binding protein in Streptococcus pneumoniae, showing it regulates cold sensitivity, phosphate transport, and virulence through post-transcriptional mechanisms.

This paper investigates FtsZ dynamics and its relationship to septal PG synthesis in Streptococcus pneumoniae, finding that FtsZ movement is continuous and independent of PG synthesis rate.

This study identifies GpsB as a cytosolic adaptor that coordinates cell wall synthesis with the bacterial cell cycle by interacting with multiple enzymes and proteins.