Author

Zongkun Shi

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Evolutionary Biology· 1

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Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Approach:statistical model· 1

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Bingjie Chen· 1 shared Chung-I Wu· 1 shared Darryl Shibata· 1 shared Haijun WeniD· 1 shared Qingjian CheniD· 1 shared

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2018-2018 · peak 1/yr

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1 shared paperEvolutionary Biology

Bingjie Chen

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Evolutionary BiologybioRxivPreprintMay 25, 2018

Quasi-neutral molecular evolution -- When positive and negative selection cancel out

Bingjie Chen, Zongkun Shi, Qingjian Chen…·Chung-I Wu

The paper shows that quasi-neutral evolution, where positive and negative selection balance, is common in somatic-cell evolution, particularly in small stem cell populations, explaining higher cancer risk in the colon compared to the small intestine.

DOI 10.1101/330811

humanstatistical model

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