Chung-I Wu

The paper uses genomic diversity data to estimate the variance ratio of reproductive output in males and females across apes and humans, finding evidence for exceptional reproductive output in some males.

This study identifies and quantifies developmental canals in C. elegans embryogenesis that suppress noise and stabilize development, revealing how cell-level stochasticity affects phenotypic outcomes.

The paper shows that quasi-neutral evolution, where positive and negative selection balance, is common in somatic-cell evolution, particularly in small stem cell populations, explaining higher cancer risk in the colon compared to the small intestine.

This study shows how a newly evolved microRNA cluster in Drosophila rewires gene regulatory networks through sequence changes, while maintaining a conserved target pool.

The paper uses foodweb theory to show weak microRNA repressions enhance gene regulatory network stability, supported by yeast and human transcriptome data and simulations.

The paper investigates how natural selection shapes the regulator-executor-phenotype architecture in yeast by analyzing morphological traits and their genetic control.

The study analyzes genetic diversity in multiple hepatocellular carcinomas, finding that low-frequency mutations pre-exist and contribute to drug resistance, presenting challenges and opportunities for cancer therapeutics.