Author
University College LondonORCID 0000-0001-5007-1761Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Alexandros Rampotas, Zoë C. Wong, Isaac Gannon…·Martin A. Pulè
A first-in-class CAR T-cell therapy targeting mutant calreticulin selectively depletes malignant stem cells in vivo and in fibrotic human organoids.
Pietro Andrei, Mariachiara Grieco, Amelia Acha‐Sagredo…·Francesca D. Ciccarelli
Kandinsky identifies and analyzes cell neighbourhoods in spatial omics data to reveal functional interactions across biological contexts.
Meng‐Lay Lin, John W. Hickey, Adam M. Passman…·Stuart A.C. McDonald
This study identifies immune cell changes and gene expression patterns in Barrett's esophagus progression to cancer using spatial and multi-omic analyses.
Piyali Ganguli, Celia De Los Angeles Colomina Basanta, Amelia Acha‐Sagredo…·Jo Spencer
The paper investigates how CDKN2A and other 9p21 gene losses influence oesophageal cancer progression, finding context-dependent effects on survival and immune infiltration.
Jinhai Deng, Teng Pan, Dan Wang…·Tony Ng
The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.
Eszter Lakatos, Vinaya Gunasri, Luis Zapata…·Trevor A. Graham
This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.
Michele Bortolomeazzi, Lucia Montorsi, Damjan Temelkovski…·Francesca D. Ciccarelli
SIMPLI is a software tool for analyzing multiplexed imaging data to enable spatially resolved single-cell tissue phenotyping and marker expression quantification.
Chandler D. Gatenbee, Ann-Marie Baker, Ryan O. Schenck…·Alexander Anderson
The paper models tumor-immune dynamics in colorectal cancer progression, showing immune evasion enables transition from immune-hot adenomas to immune-cold carcinomas.