James Anthony Howard

This study identifies GDF3 as an endogenous inhibitor of the ActE-ALK7 pathway in adipocytes, showing its role in metabolic diseases like MASLD/MASH and suggesting GDF3 inhibition as a therapeutic target.

The paper solves the crystal structure of the ActB:Fst288 complex and uses computational analysis to explain Fst288's broad antagonistic activity and specificity for activins.

This study reveals the structural basis of AMH procomplex signaling, showing how the prodomain maintains activity through a unique conformational mechanism.

This study identifies Activin E as a TGFβ ligand that signals through ALK7, using canonical activin receptors and SMAD2/3 pathways, similar to Activin C.

This study examines NET composition variability across healthy individuals and finds DNA content correlates with NET components and epithelial barrier disruption.