Author

Leonid Yurkovetskiy

University of Massachusetts Chan Medical SchoolORCID 0000-0001-5078-493XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:proteomics· 1

Frequent Co-Authors

Jeremy LubaniD· 3 shared Ann DauphiniD· 2 shared Aaron W. KollaschiD· 1 shared Alexander A. CoheniD· 1 shared Amy C ShermaniD· 1 shared Ben KotzeniD· 1 shared Daria Soto· 1 shared Debora S. MarksiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersImmunology

Jeremy LubanORCID

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3 papers

Recent·Most cited

ImmunologyImmunityPeer-reviewedMay 8, 2025

Protein design for evaluating vaccines against future viral variation

Noor Youssef, Sarah F. Gurev, Fadi Ghantous…·Debora S. Marks

The paper designs SARS-CoV-2 Spike proteins with novel mutations to evaluate vaccine effectiveness against future viral variants using a deep learning model.

36 citationstop 1%

humanproteomics

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MicrobiologybioRxivPreprintJul 12, 2024

PRC1.6 localizes on chromatin with the human silencing hub (HUSH) complex for promoter-specific silencing

Tomás Rodríguez, Leonid Yurkovetskiy, Karthika Nagalekshmi…·Jeremy Luban

The paper identifies PRC1.6 as a partner of the HUSH complex in promoter-specific provirus silencing through chromatin colocalization and functional assays.

2 citations

humanChIP-seq

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Molecular BiologyNature MicrobiologyPeer-reviewedSep 28, 2018

Primate immunodeficiency virus Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex

Leonid Yurkovetskiy, Mehmet Hakan Guney, Kyusik Kim…·Jeremy Luban

This study identifies Vpx and Vpr as viral proteins that counteract the HUSH complex to activate provirus transcription in primate immunodeficiency viruses.

143 citationstop 2%

humanexperimental assay

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