Eric Patrick Skaar

This study shows that enterobactin synthesis and uptake are essential for multi-drug resistant Klebsiella pneumoniae to grow under zinc limitation, independent of iron and Zur regulation.

This study shows diet changes during cancer chemotherapy affect gut microbiome composition and diversity, with specific nutrients linked to microbial shifts and toxicity.

This study identifies key motifs in AlkX critical for ICL repair and shows a genetic variant reduces its activity, increasing bacterial sensitivity to DNA crosslinking.

This paper identifies a 'self-gapping' mechanism in bacterial COG0523 metallochaperones where the C-terminal domain activates GTP hydrolysis via an arginine finger and lysine residue, revealing a novel regulatory mechanism.

This study compares the gut microbiome and butyrate levels in children with asymptomatic C. difficile colonization and symptomatic CDI, finding distinct microbial and butyrate profiles associated with symptom status.

This study shows that SLC11A2 in intestinal epithelial cells restricts iron and manganese to limit Salmonella replication, highlighting its role in nutritional immunity.

This study uses chemoproteomics to show that calprotectin stress in Acinetobacter baumannii leads to undermetalation of metalloproteomes, impairing key metabolic and cellular processes.

The paper introduces Moran quadrant maps and workflows for spatial-statistical analysis of molecular imaging data, enabling scalable exploration of spatial dependence and heterogeneity.

This study identifies FapR as a regulator of HssRS-mediated heme homeostasis in B. anthracis, showing its role in maintaining membrane integrity and HssS localization.

The paper optimizes a microbial biosensor to detect and respond to the clinically relevant intestinal inflammation biomarker calprotectin.

The paper introduces a data reduction method for imaging mass spectrometry that preserves full spectrum information while achieving size reduction comparable to traditional methods.

This paper identifies genes essential for Staphylococcus aureus growth in CF sputum and shows that calprotectin and cysteine limit its growth.

This study shows that the small non-coding RNA IsrR in S. aureus regulates TCA cycle activity and virulence by controlling acnA expression and Fe uptake.

This study identifies YlaN as an Fe(II) binding protein in S. aureus that relieves Fur-mediated repression of gene expression during Fe deprivation.

This study shows that restricting arginine in Staphylococcus aureus induces antibiotic tolerance, particularly in biofilms, by inhibiting protein synthesis.