Peter James Turnbaugh

This paper develops AFMT analogs that inhibit gut bacterial L-dopa decarboxylases while reducing susceptibility to host metabolism.

This study shows diet changes during cancer chemotherapy affect gut microbiome composition and diversity, with specific nutrients linked to microbial shifts and toxicity.

This study identifies a phage-resistant sub-population of Eggerthella lenta in mice, linked to reversible genomic inversions and altered capsule production.

The paper isolates and analyzes E. lenta genomes, revealing a distinct lineage associated with inflammation and highlighting its population structure and functional diversity.

The paper analyzes microbiome data from multiple cohorts to identify consistent signatures associated with methotrexate response in rheumatoid arthritis patients.

The paper identifies a female-enriched gut bacterium, Eggerthella lenta, that drives neuroinflammation and IFN-γ via TLR2 in autoimmune disease models.

The paper identifies coordinated variation between immune systems and microbiomes in healthy humans, linking it to tonic interferon states.

This study shows that A20's M1 ubiquitin binding motif suppresses TH17/22 cell activation and IL-22-driven enteritis by regulating RORγt and epigenetic changes in T cells.

This study shows that the gut microbiome affects methotrexate pharmacology in mice and contributes to interindividual variation in drug metabolism and treatment outcomes.

The paper introduces PAMA-seq, a method for cross-domain microbial taxonomic profiling, validated on synthetic and real samples, showing improved accuracy and efficiency over existing methods.

The paper identifies full-length and split homologs of human xenobiotic metabolism proteins in the gut microbiome, revealing their roles in drug metabolism and highlighting potential implications for microbial contributions to xenobiotic processing.

This study shows gut bacteria produce lactate that increases lung epithelial mitochondrial activity and worsens acute lung injury.

This study shows that a ketogenic diet reduces autoimmune disease in mice by altering host metabolism and shaping gut microbiota, specifically through β-hydroxybutyrate and Lactobacillus species.

The paper shows that a bacterial operon in the gut microbiome can reduce drug toxicity during cancer treatment by inactivating 5-fluorouracil.

This study shows that methotrexate, a non-antibiotic drug, alters the human gut microbiota, favoring Firmicutes over Bacteroidetes, which correlates with improved drug response in rheumatoid arthritis patients.

The paper identifies the genetic basis for the cooperative bioactivation of plant lignans by a human gut bacterial consortium, revealing a complete metabolic pathway in most human gut microbiomes.

This paper introduces SMURF, a method to combine 16S rRNA gene sequencing from multiple regions to improve microbial community resolution.