John H.J. Petrini

The paper shows that Mre11 deficiency leads to an ISG signature and chromatin changes, which are reversed by IFI205 ablation, promoting oncogene-induced breast cancer.

This study shows the MRN complex is essential for both initiating and extending DNA end resection in mouse meiosis, with defects leading to spermatogenic failure.

This study shows that RTEL1 helicase regulates TERRA RNA abundance and localization, with implications for telomere stability and disease.

The paper models mutations in the Mre11 complex in yeast to show that defects in ATM signaling, rather than DNA repair, are more critical for tumor suppression.

This study shows that Nbs1mid8 mutant mice develop T cell leukemias with mutations similar to human T-ALL, suggesting Nbs1's role in Mre11 complex assembly and activity.