Efthimios M. C. Skoulakis

This study identifies cholinergic neurons as the key circuit for Neurofibromin-regulated sleep consolidation in Drosophila NF1 models, revealing Ras/MAPK signaling dysregulation and mutation-specific mechanisms.

This paper shows that physically separated Drosophila coordinate movements through a near-field magnetic radiofrequency channel, with coordination dependent on the material of the housing.

The paper shows that RpS12 induces the Xrp1short isoform in Rp+/- cells, which is necessary and sufficient for their elimination, challenging existing models of ribosomal protein-linked fitness surveillance.

This paper describes using Drosophila wing discs to study Tau-mediated disease mechanisms and screen for neuroprotective drugs, showing that human Tau causes cell death and that NAP reduces toxicity.

The paper develops an in vitro tau aggregation assay combined with machine learning to identify polymorph-specific tau inhibitors, validated in a Drosophila model.

This paper identifies a multi-node neural circuit in Drosophila that governs intramodal and cross-modal dishabituation by dynamically overriding habituation.

This study shows that Tau aggregation, not phosphorylation, is critical for neurotoxicity in Drosophila, suggesting that targeting aggregation may be more effective than targeting phosphorylation in tauopathies.

The paper identifies a gated electron transfer mechanism in rhodopsin using density-functional theory, suggesting its relevance to GPCR activation and olfactory receptors.

This study shows that Drosophila MEF2 is critical for mushroom body and wing development, with specific roles in dopamine-receptive neurons.