Kristiina Rajamäki

OMIDIENT is a multi-omics integration method that uses Dirichlet auto-encoders to improve clustering, classification, and data reconstruction across cancer types.

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.

This study identifies a novel mutation in A20 causing haploinsufficiency and shows it impairs the protein-protein interactome, leading to enhanced NLRP3 inflammasome activation through caspase-8.