Riccardo Fodde

This study shows that a Western-style diet reprograms c-Kit⁺ secretory cells into tumor-initiating cells via microbial shifts and inflammation.

The paper investigates how inflammation reprograms goblet cells into tumor-initiating cells in colon cancer using single-cell RNAseq and mutation spectrum analysis.

The paper identifies the Itg2-TGFβ axis as a regulator of partial EMT in basal-like breast cancer cells, promoting collective invasion while maintaining cell cohesion.

The paper shows that competition between NuRD and SWI/SNF chromatin remodelers regulates epithelial-mesenchymal plasticity and inflammation in oral cancer, with CDK2AP1 loss promoting pro-inflammatory responses and macrophage recruitment.

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.