Author

Jacob T. Landeck

University of Massachusetts Chan Medical SchoolORCID 0000-0001-5166-1907Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:E. coli· 1 Assay:structural biology· 1 Organism:yeast· 1

Frequent Co-Authors

Brian A. KelchiD· 2 shared Joshua PajakiD· 2 shared Emily NormaniD· 1 shared Emma L. SedivyiD· 1 shared Krishna AnandiD· 1 shared Sasha Litvak· 1 shared Xingchen LiuiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersBiochemistry

Brian A. KelchORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 2, 2025

PCNA is a Nucleotide Exchange Factor for the Clamp Loader ATPase Complex

Joshua Pajak, Jacob T. Landeck, Xingchen Liu…·Brian A. Kelch

The paper presents structures of the yeast clamp loader RFC and shows PCNA facilitates nucleotide exchange by promoting ADP release through subunit separation.

1 citation

yeaststructural biology

𝕏 PostBluesky

BiochemistryJournal of Biological ChemistryPeer-reviewedMar 14, 2024

Differences in clamp loader mechanism between bacteria and eukaryotes

Jacob T. Landeck, Joshua Pajak, Emily Norman…·Brian A. Kelch

This study compares the clamp loader mechanism in bacteria and eukaryotes, revealing structural and functional differences in clamp opening and p/t-junction binding.

10 citations

E. colicryo-EM

𝕏 PostBluesky