Author

Dandan Zhao

City Of Hope National Medical CenterORCID 0000-0001-5194-750XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:statistical model· 2 Research Focus:trajectory inference· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

David Eugene FrankhouseriD· 2 shared Denis O’MeallyiD· 2 shared Guido MarcucciiD· 2 shared Jeffery M. TrentiD· 2 shared Jihyun IrizarryiD· 2 shared Russell C. RockneiD· 2 shared Sergio BranciamoreiD· 2 shared Stephen J. FormaniD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersSystems Biology

David Eugene FrankhouserORCID

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2 papers

Recent·Most cited

Systems BiologyCancer ResearchPeer-reviewedJun 22, 2026

Longitudinal single cell RNA-sequencing reveals evolution of micro- and macro-states in chronic myeloid leukemia

David Eugene Frankhouser, Dandan Zhao, Yu-Hsuan Fu…·Guido Marcucci

The paper shows that clinically relevant leukemia phenotypes emerge at the macrostate level from single cell data, revealing how disease states aggregate from noisy single cell transcriptomes.

DOI 10.1158/0008-5472.can-25-4371

humanscRNA-seq

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Cancer BiologyLeukemiaPeer-reviewedFeb 2, 2024

State-transition Modeling of Blood Transcriptome Predicts Disease Evolution and Treatment Response in Chronic Myeloid Leukemia

David Eugene Frankhouser, Russell C. Rockne, Lisa Uechi…·Guido Marcucci

The paper uses transcriptome-based state-transition models to predict CML disease progression and treatment response using time-sequential blood samples from mice.

13 citations

mousebulk RNA-seq

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