Leonardo Vinícius Monteiro de Assis

This study shows OPN3 promotes lipofuscin accumulation in keratinocytes under blue light and its loss reduces proteomic stress responses and lipofuscin formation.

CODAC is a multicriteria method for analyzing circadian rhythms that avoids strict p-value thresholds, offering flexible rhythmicity classification and comparison across groups.

This study shows that DMMB-induced photodamage causes transcriptomic changes similar to autophagy inhibition and persistent mitochondrial dysfunction.

This study shows that hepatocyte circadian clocks regulate cholesterol metabolism and protect against MASH, with Bmal1 playing a specific role in this process.

This study examines how acute and chronic blue light exposure affects human keratinocytes, finding increased proliferation, chromatin changes, and transcriptional shifts resembling malignant transformation.

This study investigates how THRB affects diurnal hepatic lipid metabolism in adult male mice, finding THRB deficiency disrupts metabolic rhythms and promotes steatosis.

This study investigates how thyroid hormone levels affect liver circadian transcriptome rhythms in mice, identifying 516 genes as molecular markers of liver TH state.