Author

Dominic Devost

McGill UniversityORCID 0000-0001-5278-1062Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

Terence E. HébertiD· 3 shared Darlaine PétriniD· 2 shared Alan X. JiiD· 1 shared Alexander F. A. KeszeiiD· 1 shared Andrew Zhai· 1 shared Ashika Jain· 1 shared Bhavneet BhinderiD· 1 shared Caleb Kutz· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMolecular Biology

Terence E. HébertORCID

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3 papers

Recent·Most cited

Molecular BiologyInternational Journal of Molecular SciencesPeer-reviewedSep 12, 2025

Gαq-stimulated gene expression is insensitive to Bromo extra terminal domain inhibitors in HEK 293 cells

Ashika Jain, Viviane Pagé, Dominic Devost…·Jason C. Tanny

The paper tests BET protein responsiveness to G protein isoforms in HEK 293 cells and finds Gq-induced gene expression is insensitive to BET inhibitors, while Gs-induced expression is sensitive to BET degradation.

DOI 10.3390/ijms26188904

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJul 22, 2024

The Orphan G Protein-Coupled Receptor GPR52 is a Novel Regulator of Breast Cancer Multicellular Organization

Sarah Z. Hanif, CheukMan Cherie Au, Ingrid Torregroza…·Kristy A. Brown

This study shows that loss of GPR52 in breast cancer cells increases cell clustering, EMT features, and tumor burden in zebrafish, suggesting GPR52 as a potential therapeutic target.

DOI 10.1101/2024.07.22.604482

zebrafishbulk RNA-seq

𝕏 PostBluesky

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedApr 16, 2024

Structure and dynamics of a pentameric KCTD5/Cullin3/Gβγ E3 ubiquitin ligase complex

Duc Minh Nguyen, Deanna H. Rath, Dominic Devost…·Gilbert G. Privé

The paper presents the cryo-EM structure of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex, revealing its dynamic architecture and mechanism for ubiquitylating Gβγ.

18 citations

humancryo-EM

𝕏 PostBluesky