Agnieszka A. Klosowska

This study examines how Class B J-Domain Proteins enhance Hsp70-mediated protein disaggregation through autoinhibition and EEVD motif interactions.

This paper investigates the evolutionary origin of class B J-domain proteins, showing they evolved from class A duplicates by losing their zinc finger domain, enabling new functions in amyloid aggregate regulation.

This study shows Hsp110 NEF enhances Hsp70 disaggregation of protein aggregates, particularly with Class B JDPs, and disrupts JDP-Hsp70 interactions to modulate disaggregation efficiency.