Author

Hubert Wyszkowski

University of GdańskORCID 0000-0002-0450-6557Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein sequence· 2 Assay:protein structure· 2 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

Agnieszka A. KlosowskaiD· 3 shared Bartłomiej TomiczekiD· 2 shared Dominik PurzyckiiD· 2 shared Katarzyna KalinowskaiD· 2 shared Krzysztof LiberekiD· 2 shared Maria PokornowskaiD· 2 shared Wiktoria SztangierskaiD· 2 shared Agata Konieczna· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

Agnieszka A. KlosowskaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintFeb 9, 2026

Multi-Step Hsp70 Recruitment by Class B J-Domain Proteins Drives Efficient Protein Disaggregation

Hubert Wyszkowski, Agata Konieczna, Maria Pokornowska…·Agnieszka A. Klosowska

This study examines how Class B J-Domain Proteins enhance Hsp70-mediated protein disaggregation through autoinhibition and EEVD motif interactions.

DOI 10.64898/2026.02.06.704373

𝕏 PostBluesky

Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedJan 9, 2026

Origin of Class B J-domain proteins involved in amyloid transactions

Przemyslaw Domanski, Milena Stolarska, Katarzyna Kalinowska…·Bartłomiej Tomiczek

This paper investigates the evolutionary origin of class B J-domain proteins, showing they evolved from class A duplicates by losing their zinc finger domain, enabling new functions in amyloid aggregate regulation.

3 citationstop 5%

comparative / phylogenetic analysischromatin & epigenetic regulation

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BiochemistryeLifePeer-reviewedMar 13, 2024

Early Steps of Protein Disaggregation by Hsp70 Chaperone and Class B J-Domain Proteins are Shaped by Hsp110

Wiktoria Sztangierska, Hubert Wyszkowski, Maria Pokornowska…·Agnieszka A. Klosowska

This study shows Hsp110 NEF enhances Hsp70 disaggregation of protein aggregates, particularly with Class B JDPs, and disrupts JDP-Hsp70 interactions to modulate disaggregation efficiency.

18 citations

protein structureprotein sequence

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