Author

Douglas RA Silveira

King's College LondonORCID 0000-0001-5298-9592Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:ATAC-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alastair SmithiD· 1 shared Anita Krithivas GandhiiD· 1 shared Batchimeg UsukhbayariD· 1 shared Chun‐Xiao SongiD· 1 shared Lynn Swun QuekiD· 1 shared Marlen MetzneriD· 1 shared Maroof HasaniD· 1 shared Olena YavorskaiD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

Alastair SmithORCID

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1 paper

Recent·Most cited

Cancer BiologybioRxivPreprintAug 24, 2023

Dysregulation of chromatin via H3K27 methylation underpins differentiation arrest in Isocitrate dehydrogenase-mutant Acute Myeloid Leukaemia.

Douglas RA Silveira, Prodromos Chatzikyriakou, Pilar Casares Aláez…·Lynn Swun Quek

This study shows that IDH2 mutations in AML block differentiation by altering H3K27 methylation, and that Enasidenib can reverse this block by modulating chromatin states.

DOI 10.1101/2023.08.24.554641

humanscRNA-seq

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