BiophysicsbioRxivPreprint
DIFFERENTIAL SCANNING CALORIMETRY: A SUITABLE METHODOLOGY TO PROBLEM THE BINDING PROPERTIES OF BCL-2 INHIBITORS
Bircan Dinç, Berna Doğan, Thomas Mavromoustakos, Serdar Durdağı
This study evaluates the binding constants of nine BCL-2 inhibitors using DSC, showing agreement with prior biological assays and simulations, and suggests DSC's utility in high-throughput drug screening.