Alison F. Munro

The paper identifies SMAD3-driven cell state transitions as a mechanism of immunoresistance in bladder cancer and shows that SMAD3 inhibition sensitizes tumors to T cell-mediated cytotoxicity.

This study screens a large compound library across patient-derived GBM stem cells to identify effective drugs targeting tumor heterogeneity and presents validated hits for further exploration.

This study identifies a synergistic combination of FAK and MEK inhibitors that effectively targets glioblastoma heterogeneity and improves therapeutic outcomes.

This study identifies a druggable PREX2/RAC1/PI3Kβ signalling axis in BRAF-mutant melanoma that confers resistance to therapies and can be targeted to improve treatment outcomes.

The paper identifies a cytoplasmic structure, SIP, that mediates non-genetic control of cell plasticity and phenotypic states through lncRNAs and signaling pathways.

This paper shows that N-acetylcysteine reduces copper uptake rather than quenching reactive oxygen species, challenging the current understanding of copper-induced cell death mechanisms.

The paper identifies two distinct neuroinflammatory signatures in ALS cohorts using gene expression analysis and validates their association with clinical metrics.