Author

Yuchao Zhang

Guangdong Provincial People's HospitalORCID 0000-0001-5369-6441Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

Ailan Lin· 1 shared Chen ZhengiD· 1 shared Chulin ShaiD· 1 shared Fan BaiiD· 1 shared Feizhe Xiao· 1 shared Feng LuoiD· 1 shared Guoyan LuoiD· 1 shared Haifeng QianiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

Ailan Lin

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 29, 2026

Glioblastoma Hijacks Astrocyte Ribosomes to Feul Malignancy through Translatome Reprogramming

Xujia Wu, Chen Zheng, Lanjie Chen…·Nu Zhang

This study shows glioblastoma hijacks astrocyte ribosomes via tunneling nanotubes, reprograms the tumor translatome to promote malignancy, and identifies INTS12 as a therapeutic target.

DOI 10.64898/2026.10.28.762373

mousescRNA-seq

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BiochemistryNature CommunicationsPeer-reviewedAug 8, 2024

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

Tongqing Li, Xueying Liu, Haifeng Qian…·Weihong Tan

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

37 citationstop 4%

deep learningexperimental assay

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