Christopher H. Evans

This study uses bulk RNA sequencing to identify transcriptomic changes in human articular chondrocytes during replicative senescence, revealing age-related gene expression differences and sex-specific variations.

This study evaluates a gene-based method for repairing osteochondral defects in rabbits, finding improved healing at 3 months but no significant difference at 12 months compared to empty defects.

This study uses meta-analysis and multi-omics to identify inflammation, autophagy, and cellular senescence as key features of age-related KOA in mice, with unique molecular profiles distinct from post-traumatic OA.

This study identifies age-related matrix stiffness as a driver of decreased α-Klotho in chondrocytes, leading to cartilage degeneration in mice and humans.