Author

Lennart Nickel

École Polytechnique Fédérale de LausanneORCID 0000-0001-5535-4402Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:protein structure· 3 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Approach:machine learning (classical)· 1 Organism:multiple species· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Bruno E. CorreiaiD· 2 shared Martin PačesaiD· 2 shared Adaptyv Competition Organizers· 1 shared Adrie H. WestphaliD· 1 shared Ahmad Zaman Qamar· 1 shared Alex J. VecchioiD· 1 shared Alexander Naka· 1 shared Ana Alcaraz‐SernaiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBioengineering

Bruno E. CorreiaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistryProtein SciencePeer-reviewedApr 18, 2025

Improving Split-HaloTag through Computational Protein Engineering

Jonas Wilhelm, Lennart Nickel, Yin‐Hsi Lin…·Kai Johnsson

This paper improves split-HaloTag by engineering cpHalo{Delta} with computational methods to enhance thermostability and activity, reducing assay time and substrate requirements.

15 citationstop 5%

protein structureexperimental assay

𝕏 PostBluesky

BioengineeringbioRxivPreprintApr 17, 2025

Crowdsourced Protein Design: Lessons From the Adaptyv EGFR Binder Competition

Tudor‐Stefan Cotet, Igor Krawczuk, Filippo Stocco…·Adaptyv Competition Organizers

The paper analyzes a crowdsourced protein design competition, showing participants designed EGFR binders with varying affinities and highlighting challenges in benchmarking and experimental design.

26 citations

protein structuremachine learning (classical)

𝕏 PostBluesky

BioinformaticsbioRxivPreprintSep 30, 2024

✦ In-depth digest

BindCraft: one-shot design of functional protein binders

Martin Pačesa, Lennart Nickel, Christian Schellhaas…·Bruno E. Correia

Hallucinating binders by backpropagating through AlphaFold2 weights gave, across 12 targets, binders in 10-100% of the designs tested per target, mostly at nanomolar affinity.

111 citations

multiple speciesprotein structure

𝕏 PostBluesky