Christiane A. Opitz

This paper introduces two protein-protein interaction assays to measure AHR activation independent of transcriptional output, capturing agonist- and antagonist-dependent modulation across ligands and cell types.

The paper shows that mammalian cells produce certain indole and phenol metabolites, while bacterial metabolism is required for others, highlighting host contributions to circulating pools.

This study identifies SFRP1 as a therapeutic target for glioblastoma by revealing its role in reprogramming tumor methylomes and improving survival in mouse models.

This study shows that reduced EWSR1::ETS activity in Ewing sarcoma promotes immune evasion via the tryptophan-kynurenine-AHR axis, leading to worse clinical outcomes and tumor progression.

The paper develops an automated workflow and dual-column U(H)PLC-MRM-MS method to rapidly quantify amino acids and tryptophan metabolites in human serum and plasma, applied to a prostate cancer study to identify biomarkers.

This paper introduces moleculaR, a computational framework for probabilistic mapping and statistical testing of metabolites in mass spectrometry imaging data.