Author

Madlen Hotze

Universität InnsbruckORCID 0009-0001-1816-2089Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1 Cell Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Assay:metabolomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Anna-Sophia EggeriD· 4 shared Kathrin ThedieckiD· 4 shared Marcel KwiatkowskiiD· 4 shared Tobias KipuraiD· 3 shared Aaron Marcellus Paul Prowatke· 1 shared Alexa Hofer· 1 shared Alienke van PijkereniD· 1 shared André GollowitzeriD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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4 shared papersCell Biology

Anna-Sophia EggerORCID

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4 papers

Recent·Most cited

Cell BiologyThe EMBO JournalPeer-reviewedOct 20, 2025

TXNIP mediates LAT1/SLC7A5 endocytosis to reduce amino acid uptake in cells entering quiescence

Jennifer Kahlhofer, Nikolas Marchet, Kristian Zubak…·David Teis

The paper identifies TXNIP as a regulator of amino acid uptake during cellular quiescence by mediating endocytosis of the LAT1/SLC7A5 transporter.

6 citations

𝕏 PostBluesky

BioinformaticsNAR Genomics and BioinformaticsPeer-reviewedJan 7, 2025

GEMCAT - A new algorithm for gene expression-based prediction of metabolic alterations

Suraj A. Sharma, Roland Sauter, Madlen Hotze…·Ines Heiland

GEMCAT predicts metabolic changes from transcriptomics or proteomics data and validates them with metabolomics, demonstrating its utility in human cell lines and inflammatory bowel disease patients.

4 citations

humanbulk RNA-seq

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BiochemistryMetabolitesPeer-reviewedJun 30, 2024

Automated liquid handling extraction and rapid quantification of underivatized amino acids and tryptophan metabolites from human serum and plasma using dual-column U(H)PLC-MRM-MS and its application to prostate cancer study.

Tobias Kipura, Madlen Hotze, Alexa Hofer…·Marcel Kwiatkowski

The paper develops an automated workflow and dual-column U(H)PLC-MRM-MS method to rapidly quantify amino acids and tryptophan metabolites in human serum and plasma, applied to a prostate cancer study to identify biomarkers.

9 citations

humanmetabolomics

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Systems BiologyJournal of Proteome ResearchPeer-reviewedFeb 10, 2023

Proteome coverage after simultaneous proteo-metabolome liquid-liquid extraction

Alienke van Pijkeren, Anna-Sophia Egger, Madlen Hotze…·Marcel Kwiatkowski

This study compares proteome coverage and extraction efficiency of different solubilization agents in proteo-metabolome analysis using SPM-LLE and direct cell lysis.

34 citations

proteomicsmetagenomics

𝕏 PostBluesky