Prabhakar Chalise

This paper shows that combining PI3K and MAPK inhibitors effectively suppresses PDAC by targeting both pathways, with the Omipalisib/Trametinib combination showing the best results in vitro and in vivo.

This study identifies CXCL5 as a key adipose-derived chemokine that promotes immune evasion in pancreatic cancer, showing that its depletion enhances T cell infiltration and response to PD-1 checkpoint inhibitors in obese mice.

The paper introduces a machine learning method to detect brain connectomic biomarkers differentiating Alzheimer's disease and mild cognitive impairment using FDG-PET data.