Michael Nathan VanSaun

This study shows DUSP6 is upregulated in pancreatic cancer metastasis and independently influences cell migration and metabolism, suggesting it as a therapeutic target.

This paper shows that combining PI3K and MAPK inhibitors effectively suppresses PDAC by targeting both pathways, with the Omipalisib/Trametinib combination showing the best results in vitro and in vivo.

This study identifies CXCL5 as a key adipose-derived chemokine that promotes immune evasion in pancreatic cancer, showing that its depletion enhances T cell infiltration and response to PD-1 checkpoint inhibitors in obese mice.

This study uses non-contrast microCT to analyze obese adipose tissue in mice exposed to cold, revealing sex-specific thermogenic adipose formation and metabolic changes.

This study shows CREB promotes acinar-to-ductal reprogramming and pancreatic cancer progression in alcoholic pancreatitis models by enhancing fibrosis and tumor growth.