Alon Goren

The paper introduces a novel dual-spike-in normalization method for ChIP-seq, demonstrating its ability to clarify the relationship between RNA polymerase II activity and histone modifications.

Trex-QTL identifies trans-eQTLs with global effects on molecular phenotypes, showing improved power and replicating known loci in rat brain data.

This study identifies STRs associated with alternative splicing in human brain tissue and links some to disease-related GWAS signals.

This study shows that SETD5 dysfunction in astrocytes increases IL-6, which harms neurons via JAK/STAT signaling, suggesting therapeutic targeting of this pathway for ASD and ID.

Prod&PQ-seq detects and quantifies protein-protein interactions and protein abundance across different cellular conditions, showing changes in PRC2 interactions with EZH2 inhibition and H3 variants.

The paper introduces spa-ChIP-seq, an automated ChIP-seq protocol, showing it achieves comparable signal-to-noise ratios to manual methods and identifies sensitivity of weak signals to antibody-to-cell-number ratio changes.

The paper introduces PIPSORT, a method to detect shared and ancestry-specific genetic signals in complex traits, and applies it to GWAS data from diverse populations.

This study evaluates how promoter proximal short tandem repeats (STRs) affect gene expression using MPRA, identifying key factors like repeat unit sequence and copy number.

The paper identifies 119 high-confidence STR-trait associations across 93 STRs for blood and serum traits using imputed genotypes from UK Biobank data.

The paper identifies a quantitative trait locus on chromosome 13 associated with STR expansion propensity in mice, implicating Msh3 in genome-wide mutation patterns.

The paper identifies over 28,000 STRs associated with gene expression across 17 tissues and links them to complex traits like height and schizophrenia.

This paper introduces Tulip, a toolkit for simulating ChIP-seq data to evaluate analyses like peak calling and differential binding, enabling power analysis and benchmarking.

The paper investigates mitotic bookmarking through histone modifications and nucleosome deposition patterns in human cells, showing that epigenomic landscapes and modified nucleosomes contribute to chromatin reestablishment after mitosis.

This study compares monoclonal and polyclonal antibodies for ChIP-seq of histone modifications, finding monoclonals perform similarly in most cases but show differences for H3K27ac.