Dimitrios N. Sidiropoulos

The paper shows that prematurity disrupts cerebellar development by altering developmental trajectories and causing lineage-specific asynchrony in cell maturation.

STAPLE automates spatial transcriptomics analysis by integrating multiple tools into a modular framework and provides AI-driven interpretation of results.

The paper develops a 3D multi-omic pipeline using deep learning to analyze chemotherapy response in pancreatic cancer, identifying molecular signatures of resistance and fibroblast-cancer interactions.

This study models prematurity-associated insults in mice to show how different insults and their sequence alter cerebellar development and lead to distinct behavioral outcomes.

PIVOT is an open-source tool for nonlinear registration of multi-omic spatial data, demonstrating improved throughput compared to existing workflows.

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

This study uses spatial multi-omics to identify TLS-associated immune niches in PDAC that correlate with improved survival in immunotherapy responders.

This paper introduces SpaceMarkers, a method to infer molecular changes from cell-cell interactions in spatial transcriptomics data, applied to tumor-immune interactions in metastasis and immunotherapy.

BugBase assigns pathway coverage and traits (Gram stain, oxygen tolerance, pathogenicity) to individual taxa in 16S or shotgun microbiome data, detecting some functional differences bag-of-genes profiles miss.