Mark M. Yarchoan

The paper calibrates a spatial QSP model using CODEX data to predict TME states and identify biomarkers for HCC immunotherapy response.

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

This study uses spatial multi-omics to identify TLS-associated immune niches in PDAC that correlate with improved survival in immunotherapy responders.

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

This paper introduces SpaceMarkers, a method to infer molecular changes from cell-cell interactions in spatial transcriptomics data, applied to tumor-immune interactions in metastasis and immunotherapy.