Weijie Zhang

The paper introduces πDIA-CLIP, a zero-shot framework for DIA proteomics data analysis that improves protein identification and reduces false positives across diverse datasets.

This study develops a high-throughput plasma proteome analysis workflow using UV-assisted digestion, 5-plex labeling, and MS-based high abundance protein removal to improve quantification of low-abundance proteins.

SpotLink identifies site non-specific cross-links at the proteome scale with high sensitivity and precision, outperforming existing methods on simulated and protein complexes datasets.