ImmunologybioRxivPreprint
B lymphocytes acquire myeloid and autoimmune phenotypes via the downregulation of lymphocyte-specific protein-1
Naeun Lee, Bong‐Ki Hong, Sungyong You…·Wan‐Uk Kim
This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.