Sungyong You

This study shows that large oncosomes reprogram bone marrow mesenchymal stem cells to create a pre-metastatic niche by inducing an interferon-driven inflammatory response.

The paper maps the spatial organization of lung cancer ecosystems in mice and humans, identifying distinct spatial domains that reveal tumor heterogeneity and immune interactions.

This study identifies pro-inflammatory monocyte and macrophage subsets driven by lupus immune complexes, independent of type I interferon signaling, using scRNA-seq and proteomic analysis.

This study provides a multiomics resource of cancer extracellular vesicles, showing correlations between LO proteins and prostate cancer progression, and demonstrating the feasibility of single-cell RNA-Seq on EVs.

This study identifies a RIPK2-regulated gene signature that correlates with prognosis in prostate cancer and responds to RIPK2 inhibitors.

This study shows that LSP1 deficiency in B cells leads to myeloid-like traits and autoantibody production, accelerating lupus in mice and correlating with reduced LSP1 in lupus patients.

This study identifies ONECUT2 as a master transcription factor that drives resistance in prostate cancer through multiple mechanisms, including activation of neuroendocrine and adenocarcinoma variants, and shows that its inhibition can suppress treatment-resistant lineage plasticity.

This study shows that TDP2 regulates estrogen-induced oncogene expression by resolving TOP2-induced DNA breaks, affecting MYC and CCND1 in ER-positive cells and mice.