Volker Briken

This study shows that deleting the pknF gene in Mycobacterium tuberculosis increases its virulence in mice by enhancing production of the pro-virulence lipid PDIM and reducing host survival.

This study identifies that Mtb-infected macrophages undergo cell death without canonical pathways, correlating with DNA release similar to NETosis.

This study shows Salmonella Typhimurium inhibits macrophage IFNbeta signaling via TLR4, but IFNbeta does not affect host defense against STm.

The paper introduces da_Tracker, an automated workflow for high-throughput single-cell and single-phagosome tracking in infected cells, enabling quantitative analysis of pathogen-host interactions.

This paper introduces two automated methods for quantifying bacterial burden in macrophages using confocal microscopy, validated with Salmonella and Mycobacterium models.

This study shows Mycobacterium tuberculosis inhibits IFN-β signaling in macrophages to enhance its survival by reducing phosphorylation of JAK1, TYK2, STAT1, and STAT2.