Shobha Vasudevan

This study identifies a JNK-STAT1 pathway that regulates IFN-stimulated genes and cell adhesion in quiescent leukemic cells, contributing to chemoresistance.

The paper shows that miR-181d degradation via a PNPT1-ATR feed-forward loop increases MGMT expression variance, leading to temozolomide resistance in glioblastoma cells.

BAMBI identifies coding and non-coding RNA genes as biomarkers for disease diagnosis and prognosis with high accuracy and biological interpretability.

The paper shows that therapy-induced stress increases METTL3 translation, altering gene expression to promote tumor survival.

The paper shows FXR1 alters ribosomes in quiescent leukemic cells, inducing stress signals to enable non-canonical translation for chemosurvival.

This study identifies a post-transcriptional mechanism of chemoresistance in leukemia involving AU-rich elements and TTP regulation.