Author
University of PennsylvaniaORCID 0000-0001-5986-504XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Conroy O. Field, Amrita Sarkar, Khalil H. Bdeir…·Mortimer Poncz
This study identifies PF4 as a central factor in APS by showing it bridges {beta}2GPI to NETs, forming prothrombotic complexes that are targeted by APS antibodies.
Tatiana V. Kudryashova, Sergei V Zaitsev, Lifeng Jiang…·Victoria V. Stepanova
This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.
Mortimer Poncz, Sergei V Zaitsev, Hyun-Sook Ahn…·Victoria V. Stepanova
The paper demonstrates that in vitro-grown megakaryocytes can store exogenous uPA in alpha-granules, which can be used to generate anti-thrombotic human platelets that lyse nascent thrombi in a mouse model.