Author

Sergei V Zaitsev

Children's Hospital of PhiladelphiaORCID 0000-0001-9597-9183Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Douglas B. CinesiD· 2 shared Mortimer PoncziD· 2 shared Victoria V. StepanovaiD· 2 shared Aisha Saiyed· 1 shared Andressa Z. PenaiD· 1 shared Benjamin J. BuckleyiD· 1 shared Bryce PiperiD· 1 shared Derek Lin· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Douglas B. CinesORCID

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2 papers

Recent·Most cited

Cell BiologyAmerican Journal of Physiology-Lung Cellular and Molecular PhysiologyPeer-reviewedJun 11, 2024

PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hy-pertension

Tatiana V. Kudryashova, Sergei V Zaitsev, Lifeng Jiang…·Victoria V. Stepanova

This study shows PAI-1 deficiency in PASMC promotes pulmonary vascular remodeling and hypertension by enhancing uPA activity, leading to cell proliferation and reduced apoptosis.

11 citations

mousehuman

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Cell BiologybioRxivPreprintDec 5, 2023

Packaging of supplemented urokinase into naked alpha-granules of in vitro-grown megakaryocytes for targeted therapeutic delivery

Mortimer Poncz, Sergei V Zaitsev, Hyun-Sook Ahn…·Victoria V. Stepanova

The paper demonstrates that in vitro-grown megakaryocytes can store exogenous uPA in alpha-granules, which can be used to generate anti-thrombotic human platelets that lyse nascent thrombi in a mouse model.

DOI 10.1101/2023.12.05.570278

mouseproteomics

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