Author

Kirk J. Wangensteen

University of PennsylvaniaORCID 0000-0001-6042-6490Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Adam M. ZahmiD· 3 shared Klaus H. KaestneriD· 3 shared Amber W. Wang· 2 shared Yue Julia WangiD· 2 shared Alexandra M. Vázquez-Salgado· 1 shared Ashleigh R. Morgan· 1 shared Daniel AckermaniD· 1 shared Jonathan SchugiD· 1 shared

Activity by Year

2019-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersGenomics

Adam M. ZahmORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

GenomicsCellular and Molecular Gastroenterology and HepatologyPeer-reviewedOct 17, 2019

The dynamic chromatin architecture of the regenerating liver

Amber W. Wang, Yue Julia Wang, Adam M. Zahm…·Klaus H. Kaestner

The paper identifies CTCF and HNF4 as key regulators of hepatocyte proliferation and metabolic regulation during liver regeneration using ATAC-seq and ChIP-seq in a mouse model.

51 citationstop 5%

mouseATAC-seq

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Cancer BiologybioRxivPreprintJun 13, 2019

In vivo screen identifies LXR agonism potentiates sorafenib killing of hepatocellular carcinoma

Morgan E. Preziosi, Adam M. Zahm, Alexandra M. Vázquez-Salgado…·Kirk J. Wangensteen

The paper identifies LXR agonism as a potential enhancer of sorafenib's efficacy in treating hepatocellular carcinoma through an in vivo genetic screen and mechanistic studies.

DOI 10.1101/668350

mousebulk RNA-seq

𝕏 PostBluesky

Systems BiologybioRxivPreprintJun 11, 2019

A high-content in vivo screen to identify microRNA epistasis in the repopulating mouse liver

Adam M. Zahm, Amber W. Wang, Yue Julia Wang…·Klaus H. Kaestner

The paper identifies miRNA epistasis in liver regeneration using a high-content in vivo screen in mice, revealing synergistic and redundant effects of miRNA interactions.

DOI 10.1101/664847

mouseexperimental assay

𝕏 PostBluesky