Cell BiologyPLoS ONEPeer-reviewed
Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2
Tom Cremer, Hanneke Hoelen, Michael L. van de Weijer…·Emmanuel J. H. J. Wiertz
This study identifies UBE2G2 as a key enzyme in the ERAD-mediated degradation of proinsulin, leading to the presentation of a proinsulin B-chain autoantigen in T1D.
6 citations