Carlos Vela‐Rodríguez

This study shows that dimerization of PARP15 is necessary for NAD+ binding and automodification, supported by structural and biochemical evidence.

The paper develops a FRET-based assay to identify small molecules that inhibit collagen prolyl 4-hydroxylases by targeting their peptide-substrate-binding domain, leading to the discovery of a selective inhibitor.

This study identifies the D2 domain of DTX3L as critical for forming oligomeric complexes that enable the DTX3L-PARP9 complex to read mono-ADP-ribosylated androgen receptor.